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CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.

Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8+T Cells Requires the Presence of Cognate Antigen

Adoptive Immunotherapy against Experimental Visceral Leishmaniasis with CD8⁺T Cells Requires the Presence of Cognate Antigen