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Recombinant adenylate cyclase toxoids are shown to deliver inserted foreign CD4+ -T-cell epitopes into the major histocompatibility complex class II presentation pathway, inducing a specific CD4+ -T-cell response in vivo and yielding in vitro stimulation of specific CD4+ T cells at a 100-times-higher molar efficiency than the free peptide containing the epitope.

infection and immunity

Delivery of a MalE CD4 <sup>+</sup> -T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by <i>Bordetella pertussis</i> Adenylate Cyclase

Delivery of a MalE CD4 + -T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase

Delivery of a MalE CD4 ⁺ -T-Cell Epitope into the Major Histocompatibility Complex Class II Antigen Presentation Pathway by Bordetella pertussis Adenylate Cyclase