English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

WbpM is a highly conserved protein involved in synthesis of the O antigens ofPseudomonas aeruginosa . Homologues of this protein have been identified in a large number of bacteria, and they can be divided into two subfamilies: subfamily 1, including WbpM, contains large proteins (∼600 amino acids), while subfamily 2, typified by HP0840 (FlaA1) ofHelicobacter pylori , contains smaller proteins (∼350 amino acids) homologous to the C termini of proteins in subfamily 1. Analysis of knockout mutants ofwbpM inP. aeruginosa serotypes O3, O10, O15, and O17 showed that although all 20 serotypes ofP. aeruginosa possesswbpM , it is not universally required for O-antigen biosynthesis. Homologous genes fromBordetella pertussis (wlbL ),Staphylococcus aureus (cap8D ), andH. pylori (flaA1 ) complemented aP. aeruginosa O5wbpM mutant to various degrees. These conserved proteins may represent interesting targets for the design of inhibitors of bacterial exopolysaccharide biosynthesis.

infection and immunity

Functional Conservation of the Polysaccharide Biosynthetic Protein WbpM and Its Homologues in <i>Pseudomonas aeruginosa</i> and Other Medically Significant Bacteria

Functional Conservation of the Polysaccharide Biosynthetic Protein WbpM and Its Homologues in Pseudomonas aeruginosa and Other Medically Significant Bacteria