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Differences in susceptibility to persistent cryptosporidial infection between two strains of adult athymic nude mice prompted us to investigate the immune mechanism(s) that may control resistance to infection in these T-cell-deficient mice. We studied fecal oocyst shedding, serum and fecal parasite-specific antibody responses, and fecal immunoglobulin levels in athymic C57BL/6J nude and athymic BALB/cJ nude mice following oral inoculation withCryptosporidium parvum oocysts at 8 to 9 weeks of age. C57BL/6J nude mice had significantly higher fecal parasite-specific immunoglobulin A (IgA) (days 27, 31, 35, and 42 postinoculation) and IgM (days 10, 17, 24, 28, 31, 38, 42, and 48 postinoculation) levels than BALB/cJ nude mice (P &lt; 0.05) and significantly higher serum parasite-specific IgA levels at 63 days postinoculation (P &lt; 0.03). Moreover, C57BL/6J nude mice shed significantly fewerC. parvum oocysts than BALB/cJ nude mice from days 52 to 63 postinoculation (P &lt; 0.05). In contrast, BALB/cJ nude mice had higher levels of non-parasite-specific IgA (days 38 to 63 postinoculation) and IgM (days 24, 35, 38, and 52 postinoculation) than C57BL/6J nude mice in feces (P &lt; 0.05). These data suggest that parasite-specific fecal antibodies may be associated with resistance toC. parvum in C57BL/6J nude mice.

Evidence of Thymus-Independent Local and Systemic Antibody Responses toCryptosporidium parvumInfection in Nude Mice