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A genetic locus affecting susceptibility to the bactericidal activity of normal human serum has been designatedsac-1 . This locus was shown to be closely linked to, but not identical with, a second locus (designatednmp-2 ) that affects protein 1 of the outer membrane. Thesac-1 locus could be linked to known antibiotic resistance markers on the gonococcal chromosome by genetic transformation.

Genetics of Serum Resistance in Neisseria gonorrhoeae : The sac-1 Genetic Locus