English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Acute alloxan diabetic rabbits were used in a survey of the potential ability ofAbsidia, Cunninghamella, Mucor, Rhizopus, Syncephalastrum , andThamnidium species to cause cerebral zygomycosis (phycomycosis, mucormycosis). Specifically, the correlation of thermotolerance with potential pathogenicity was studied. The test organisms fell into two groups: those able to grow well at 39 C on Sabouraud dextrose agar and those unable to grow at that temperature. Isolates unable to grow at 39 C were not pathogenic. The nonpathogens wereC. elegans, M. jansenni, R. reflexus, R. stolonifer , andT. elegans . Two isolates ofS. racemosum and one isolate ofA. corymbifera , although able to grow well at 39 C in vitro, did not invade the brain or lungs of acutely diabetic rabbits. Three species ofRhizopus, R. chinensis, R. microsporus , andR. oligosporus , all of which grew at 39 C and which had not been previously known to cause cerebral zygomycosis, were as pathogenic as the only two previously implicated disease agents,R. arrhizus andR. oryzae . Studies were also carried out to determine whether animals inoculated with spores of selected zygomycetes many hours prior to the onset of acute diabetes would develop cerebral zygomycosis. Approximately 50% of the rabbits that became acutely diabetic 72 to 90 hr after receivingR. oryzae spores by nasal instillation succumbed to cerebral zygomycosis. Our study indicates that several members of the genusRhizopus that grow well at 39 C or higher, other thanR. arrhizus andR. oryzae , are potential etiological agents of cerebral zygomycosis.

Experimental Cerebral Zygomycosis in Alloxan-Diabetic Rabbits I. Relationship of Temperature Tolerance of Selected Zygomycetes to Pathogenicity