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Candida albicans is normally a commensal fungus of the human mucosae and skin, but it causes life-threatening systemic infections in hospital settings in the face of predisposing conditions, such as indwelling catheters, abdominal surgery, or antibiotic use. Immunity toC. albicans involves various immune parameters, but the cytokine interleukin-17A (IL-17A) (also known as IL-17) has emerged as a centrally important mediator of immune defense against both mucosal and systemic candidiasis. Conversely, IL-17A has been suggested to enhance the virulence ofC. albicans , indicating that it may exert detrimental effects on pathogenesis. In this study, we hypothesized that aC. albicans strain expressing IL-17A would exhibit reduced virulencein vivo . To that end, we created aCandida -optimized expression cassette encoding murine IL-17A, which was transformed into the DAY286 strain ofC. albicans .Candida -derived IL-17A was indistinguishable from murine IL-17A in terms of biological activity and detection in standard enzyme-linked immunosorbent assays (ELISAs). Expression of IL-17A did not negatively impact the growth of these strainsin vitro . Moreover, the IL-17A-expressingC. albicans strains showed significantly reduced pathogenicity in a systemic model ofCandida infection, mainly evident during the early stages of disease. Collectively, these findings suggest that IL-17A mitigates the virulence ofC. albicans .

A Candida albicans Strain Expressing Mammalian Interleukin-17A Results in Early Control of Fungal Growth during Disseminated Infection