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Despite the fact that the regulatory system sensing density of cell population and its signaling molecule have been identified inSalmonella enterica , the biological significance of this phenomenon termed as quorum sensing remains unknown. In this report, we provide evidence that theluxS gene is necessary forSalmonella virulence phenotypes. Transcription assays showed that the cell-density-dependent induction of theinvF gene was abolished in aSalmonella strain with theluxS gene deleted. The effect of theluxS deletion was also investigated in other InvF-regulated genes expressed fromSalmonella pathogenicity island 1 (SPI-1). The decreased expression of SPI-1 genes in the strain withluxS deleted could be restored by either the addition of a synthetic signal molecule or the introduction of a plasmid copy of theluxS gene. Thus, the reduced expression ofinvF and its regulated genes inSalmonella cells lacking quorum sensing resulted in the attenuation of virulence phenotypes both in vitro and in vivo.

infection and immunity

Implication of Quorum Sensing in<i>Salmonella enterica</i>Serovar Typhimurium Virulence: the<i>luxS</i>Gene Is Necessary for Expression of Genes in Pathogenicity Island 1

Implication of Quorum Sensing inSalmonella entericaSerovar Typhimurium Virulence: theluxSGene Is Necessary for Expression of Genes in Pathogenicity Island 1