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The nontyphoidalSalmonella enterica serovar Dublin is adapted to cattle but infrequently infects humans, very often resulting in invasive infections with high levels of morbidity and mortality. ASalmonella -induced intestinal acute inflammatory response is postulated as a mechanism to prevent bacterial dissemination to systemic sites. InS. enterica serovar Typhimurium, flagella contribute to this response by providing motility and FliC-mediated activation of pattern recognition receptors. In this study, we found 4Salmonella enterica isolates, with the antigenic formula 9,12:−:−, that, based onfliC sequence and multilocus sequence type (MLST) analyses, are aflagellateS . Dublin isolates. Interestingly, all were obtained from human bloodstream infections. Thus, we investigated the potential role of flagella in the unusual invasiveness exhibited byS . Dublin in humans by analyzing flagellation and proinflammatory properties of a collection of 10S . Dublin human clinical isolates. We found that 4 of 7 blood isolates were aflagellate due to significantly reduced levels offliC expression, whereas all 3 isolates from other sources were flagellated. Lack of flagella correlated with a reduced ability of triggering interleukin-8 (IL-8) and CCL20 chemokine expression in human intestinal Caco-2 cells and with reduced early inflammation in the ceca of streptomycin-pretreated C57/BL6 mice. These results indicate that flagella contribute to the host intestinal inflammatory response toSalmonella serovar Dublin and suggest that their absence may contribute to its systemic dissemination through dampening of the gut immune response. Analysis of FliC production in a collection of cattle isolates indicated that the aflagellate phenotype is widely distributed in field isolates ofS . Dublin.

Repression of Flagella Is a Common Trait in Field Isolates of Salmonella enterica Serovar Dublin and Is Associated with Invasive Human Infections