English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

IL12RB1 is a human gene that is important for resistance toMycobacterium tuberculosis infection.IL12RB1 is expressed by multiple leukocyte lineages, and encodes a type I transmembrane protein (IL12Rβ1) that associates with IL12p40 and promotes the development of host-protective TH 1cells. Recently, we observed thatil12rb1 —the mouse homolog ofIL12RB1 —is alternatively spliced by leukocytes to produce a second isoform (IL12Rβ1ΔTM) that has biological properties distinct from IL12Rβ1. Although the expression of IL12Rβ1ΔTM is elicited byM. tuberculosis in vivo , and its overexpression enhances IL12p40 responsivenessin vitro , the contribution of IL12Rβ1ΔTM to controllingM. tuberculosis infection has not been tested. Here, we demonstrate that IL12Rβ1ΔTM represents a secreted product ofil12rb1 that, when absent from mice, compromises their ability to controlM. tuberculosis infection in extrapulmonary organs. Furthermore, elevatedM. tuberculosis burdens in IL12Rβ1ΔTM-deficient animals are associated with decreased lymph node cellularity and a decline in TH 1 development. Collectively, these data support a model wherein IL12Rβ1ΔTM is a secreted product ofil12rb1 that promotes resistance toM. tuberculosis infection by potentiating TH cells response to IL-12.

IL12Rβ1ΔTM Is a Secreted Product ofil12rb1That Promotes Control of Extrapulmonary Tuberculosis