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Little is known about whether pathogen invasion of neural tissue is affected by immune-based mechanisms in endothelial cells. We examined the effects of endothelial cell CD40 onToxoplasma gondii invasion of the retina and brain, organs seeded hematogenously.T. gondii circulates in the bloodstream within infected leukocytes (including monocytes and dendritic cells) and as extracellular tachyzoites.

CD40 in Endothelial Cells Restricts Neural Tissue Invasion by Toxoplasma gondii