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Streptococcus pneumoniae is a frequent colonizer of the upper respiratory tract and a leading cause of bacterial pneumonia. The innate immune system senses pneumococcal cell wall components, toxin, and nucleic acids, which leads to production of inflammatory mediators to initiate and control antibacterial defense. Here, we show that the cGAS (cyclic GMP-AMP [cGAMP] synthase)-STING pathway mediates detection of pneumococcal DNA in mouse macrophages to primarily stimulate type I interferon (IFN) responses. Cells of human individuals carryingHAQ TMEM173 , which encodes a common hypomorphic variant of STING, were largely or partly defective in inducing type I IFNs and proinflammatory cytokines upon infection. Subsequent analyses, however, revealed that STING was dispensable for restrictingS. pneumoniae during acute pneumonia in mice. Moreover, explorative analyses did not find differences in the allele frequency ofHAQ TMEM173 in nonvaccinated pneumococcal pneumonia patients and healthy controls or an association ofHAQ TMEM173 carriage with disease severity. Together, our results indicate that the cGAS/STING pathway sensesS. pneumoniae but plays no major role in antipneumococcal immunity in mice and humans.

The cGAS/STING Pathway Detects Streptococcus pneumoniae but Appears Dispensable for Antipneumococcal Defense in Mice and Humans