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To determine the ability of the major outer membrane protein (MOMP) to elicit cross-serovar protection, groups of mice were immunized by the intramuscular (i.m.) and subcutaneous (s.c.) routes with recombinant MOMP (rMOMP) fromChlamydia trachomatis serovars D (UW-3/Cx), E (Bour), or F (IC-Cal-3) orChlamydia muridarum strain Nigg II using CpG-1826 and Montanide ISA 720 VG as adjuvants. Negative-control groups were immunized i.m. and s.c. withNeisseria gonorrhoeae recombinant porin B (Ng -rPorB) or i.n. with Eagle's minimal essential medium (MEM-0). Following vaccination, the mice developed antibodies not only against the homologous serovar but also against heterologous serovars. The rMOMP-vaccinated animals also mounted cell-mediated immune responses as assessed by a lymphoproliferative assay. Four weeks after the last immunization, mice were challenged i.n. with 104 inclusion-forming units (IFU) ofC. muridarum . The mice were weighed for 10 days and euthanized, and the number of IFU in their lungs was determined. At 10 days postinfection (p.i.), mice immunized with the rMOMP ofC. muridarum orC. trachomatis D, E, or F had lost 4%, 6%, 8%, and 8% of their initial body weight, respectively, significantly different from the negative-control groups (Ng -rPorB, 13%; MEM-0, 19%;P &lt; 0.05). The median number of IFU recovered from the lungs of mice immunized withC. muridarum rMOMP was 0.13 × 106 . The median number of IFU recovered from mice immunized with rMOMP from serovars D, E, and F were 0.38 × 106 , 7.56 × 106 , and 11.94 × 106 IFU, respectively. All the rMOMP-immunized animals had significantly less IFU than theNg -rPorB (40 × 106 )- or MEM-0 (70 × 106 )-immunized mice (P &lt; 0.05). In conclusion, vaccination with rMOMP can elicit protection against homologous and heterologousChlamydia serovars.

infection and immunity

Vaccination with the Recombinant Major Outer Membrane Protein Elicits Antibodies to the Constant Domains and Induces Cross-Serovar Protection against Intranasal Challenge with Chlamydia trachomatis