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In serogroup CNeisseria meningitidis , thecssA (siaA ) gene codes for an UDP-N -acetylglucosamine 2-epimerase that catalyzes the conversion of UDP-N -acetyl-α-d -glucosamine intoN -acetyl-d -mannosamine and UDP in the first step in sialic acid biosynthesis. This enzyme is required for the biosynthesis of the (α2→9)-linked polysialic acid capsule and for lipooligosaccharide (LOS) sialylation.

infection and immunity

Virulence Traits of a Serogroup C Meningococcus and Isogenic <i>cssA</i> Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis

Virulence Traits of a Serogroup C Meningococcus and Isogenic cssA Mutant, Defective in Surface-Exposed Sialic Acid, in a Murine Model of Meningitis