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Swine erysipelas is caused by the Gram-positive pathogenErysipelothrix rhusiopathiae . The swine erysipelas live vaccine in Japan, theE. rhusiopathiae Koganei 65-0.15 strain (Koganei), has been reported to cause arthritis and endocarditis. To develop a vaccine with increased safety, we used a virulent Fujisawa strain to construct transposon mutants for a total of 651 genes, which covered 38% of the coding sequence of the genome.

infection and immunity

Genome-Wide Identification of Virulence Genes in <i>Erysipelothrix rhusiopathiae</i> : Use of a Mutant Deficient in a <i>tagF</i> Homolog as a Safe Oral Vaccine against Swine Erysipelas

Genome-Wide Identification of Virulence Genes in Erysipelothrix rhusiopathiae : Use of a Mutant Deficient in a tagF Homolog as a Safe Oral Vaccine against Swine Erysipelas