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Clostridium difficile is an anaerobic, spore-forming bacterium capable of colonizing the gastrointestinal tract of humans following disruption of the normal microbiota, typically from antibiotic therapy for an unrelated infection. With approximately 500,000 confirmed infections leading to 29,000 deaths per year in the United States,C. difficile infection (CDI) is an urgent public health threat.

Cysteine Desulfurase IscS2 Plays a Role in Oxygen Resistance in Clostridium difficile