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In silico analyses ofTreponema pallidum subsp.pallidum genomes and predicted proteomes to search for homologs of known bacterial outer membrane proteins (OMPs) led to the identification oftp0126 as a gene encoding a putative member of the OmpW family of porins/virulence factors. Our previous investigations on the role of Tp0126 inT. pallidum biology and syphilis pathogenesis showed that Tp0126 is fully conserved amongT. pallidum strains and that transcription oftp0126 is driven by σ70 .

Evaluation of the Protective Ability of the Treponema pallidum subsp.pallidumTp0126 OmpW Homolog in the Rabbit Model of Syphilis