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Lyme disease (LD), the most prevalent vector-borne illness in the United States and Europe, is caused byBorreliella burgdorferi . No vaccine is available for humans. Dogmatically,B. burgdorferi can establish a persistent infection in the mammalian host (e.g., mice) due to a surface antigen, VlsE. This antigenically variable protein allows the spirochete to continually evade borreliacidal antibodies.

Delineating Surface Epitopes of Lyme Disease Pathogen Targeted by Highly Protective Antibodies of New Zealand White Rabbits