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Salivary proline-rich proteins (PRPs) attach commensalActinomyces andStreptococcus species to teeth. Here, gel filtration, mass spectrometry and Edman degradation were applied to show the release of a pentapeptide, RGRPQ, from PRP-1 upon proteolysis byStreptococcus gordonii . Moreover, synthetic RGRPQ and derivatives were used to investigate associated innate properties and responsible motifs. The RGRPQ peptide increased 2.5-fold the growth rate ofS. gordonii via a Q-dependent sequence motif and selectively stimulated oral colonization of this organism in a rat model in vivo. In contrast, the growth ofStreptococcus mutans , implicated in caries, was not affected. While the entire RGRPQ sequence was required to block sucrose-induced pH-decrease byS. gordonii andS. mutans , the N-terminal Arg residue mediated the pH increase (i.e., ammonia production) byS. gordonii alone (which exhibits Arg catabolism to ammonia). Strains of commensal viridans streptococci exhibited PRP degradation and Arg catabolism, whereas cariogenic species did not. The RGRPQ peptide mediated via a differential Q-dependent sequence motif, adhesion inhibition, and desorption of PRP-1-binding strains ofA. naeslundii genospecies 2 (5 of 10 strains) but not ofS. gordonii (n = 5). The inhibitableA. naeslundii strains alone displayed the same binding profile asS. gordonii to hybrid peptides terminating in RGRPQ or GQSPQ, derived from the middle or C-terminal segments of PRP-1. The present findings indicate the presence of a host-bacterium interaction in which a host peptide released by bacterial proteolysis affects key properties in biofilm formation.

infection and immunity

Host-Derived Pentapeptide Affecting Adhesion, Proliferation, and Local pH in Biofilm Communities Composed of <i>Streptococcus</i> and <i>Actinomyces</i> Species

Host-Derived Pentapeptide Affecting Adhesion, Proliferation, and Local pH in Biofilm Communities Composed of Streptococcus and Actinomyces Species