Open AccessMicafungin Enhances Neutrophil Fungicidal Functions against Candida Pseudohyphae
Author(s) -
Cristina Gil-Lamaignere,
Stefanie Salvenmoser,
Regina Hess,
F. Müller
Publication year - 2004
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.48.7.2730-2732.2004
Subject(s) - candida albicans , micafungin , candida dubliniensis , microbiology and biotechnology , hypha , granulocyte , chemistry , corpus albicans , fungicide , pharmacology , biology , antifungal , amphotericin b , immunology , botany
We evaluated the effect of the combination of micafungin and polymorphonuclear leukocytes (PMN) against hyphae of Candida albicans and Candida dubliniensis. Micafungin enhanced the PMN oxidative burst dose dependently. The combination was synergistic (C. albicans) or additive (C. dubliniensis); when PMN were pretreated with granulocyte-macrophage colony-stimulating factor, the combination was more effective.