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The MICs of 24 antimicrobials for 26 Leptospira spp. serovars were determined using a broth microdilution technique. The MICs at which 90% of isolates tested were inhibited (MIC(90)s) of cefepime, imipenem-cilastatin, erythromycin, clarithromycin, and telithromycin were all &lt;/=0.01 microg/ml. The MIC(90)s of amoxicillin, aztreonam, cefdinir, chloramphenicol, and penicillin G were &gt;/=3.13 microg/ml. Many antimicrobials have excellent in vitro activity against Leptospira.

Determination of Susceptibilities of 26 Leptospira sp. Serovars to 24 Antimicrobial Agents by a Broth Microdilution Technique