Open AccessEffects of 16S rRNA Gene Mutations on Tetracycline Resistance in Helicobacter pylori
Author(s) -
Monique M. Gerrits,
Marco Berning,
Arnoud H. M. van Vliet,
Ernst J. Kuipers,
Johannes G. Kusters
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.9.2984-2986.2003
Subject(s) - tetracycline , helicobacter pylori , biology , mutation , microbiology and biotechnology , 16s ribosomal rna , gene , genetics , antibiotics
The triple-base-pair 16S rDNA mutation AGA(926-928)-->TTC mediates high-level tetracycline resistance in Helicobacter pylori. In contrast, single- and double-base-pair mutations mediated only low-level tetracycline resistance and decreased growth rates in the presence of tetracycline, explaining the preference for the TTC mutation in tetracycline-resistant H. pylori isolates.