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Although the antimicrobial effects of silver salts were noticed long ago, the molecular mechanism of the bactericidal action of Ag(+) in low concentrations has not been elucidated. Here, we show that low concentrations of Ag(+) induce a massive proton leakage through the Vibrio cholerae membrane, which results in complete deenergization and, with a high degree of probability, cell death.

Chemiosmotic Mechanism of Antimicrobial Activity of Ag + in Vibrio cholerae

Chemiosmotic Mechanism of Antimicrobial Activity of Ag ⁺ in Vibrio cholerae