Open AccessActivity of BMS-284756, a Novel Des-Fluoro(6) Quinolone, against Staphylococcus aureus , Including Contributions of Mutations to Quinolone Resistance
Author(s) -
Donald E. Low,
Matthew Muller,
Carla Duncan,
Barbara M. Willey,
Joyce C. de Azavedo,
Allison McGeer,
Barry N. Kreiswirth,
Sylvia Pong-Porter,
Darrin J. Bast
Publication year - 2002
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.46.4.1119-1121.2002
Subject(s) - ciprofloxacin , quinolone , staphylococcus aureus , microbiology and biotechnology , antibacterial agent , in vitro , biology , minimum inhibitory concentration , staphylococcus , antibiotics , bacteria , genetics
The in vitro activity of BMS-284756 against 602 Staphylococcus aureus isolates, including 152 that were both methicillin and ciprofloxacin resistant (MIC > or = 4 microg/ml), was determined. For ciprofloxacin-susceptible and nonsusceptible isolates, the MICs at which 50% of organisms were inhibited were 0.015 and 2 microg/ml and the MICs at which 90% of organisms were inhibited were 0.03 and 4 microg/ml, respectively.