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A Pseudomonas aeruginosa isolate highly resistant to carbapenems was collected from a patient with postsurgical cerebrospinal infection in Greece. The isolate carried a class 1 integron that contained as a sole cassette the gene bla(VIM-4), a novel variant of bla(VIM-1), with one nucleotide difference resulting in a Ser-to-Arg change at amino acid position 175 of the VIM-1 enzyme. This is the first detection of a VIM-1 variant after its appearance in Italy.

antimicrobial agents and chemotherapy

Novel Variant ( bla VIM-4 ) of the Metallo-β-Lactamase Gene bla VIM-1 in a Clinical Strain of Pseudomonas aeruginosa