Open AccessAntibacterial Properties of Gemifloxacin and Trovafloxacin in Urine Ex Vivo: Phase I Study
Author(s) -
Gloria Garcı́a-Calvo,
Araceli Parra,
Lorenzo Aguilar,
Carmen Ponte,
Marı́a José Giménez,
Antonio J. Carcas,
Martina KinzigSchippers,
Francisco Soriano
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.6.1876-1878.2001
Subject(s) - trovafloxacin , gemifloxacin , ex vivo , urine , antibacterial agent , in vivo , antibiotics , microbiology and biotechnology , pharmacology , medicine , chemistry , biology
Urine bactericidal titers (UBTs) against Escherichia coli ATCC 25922 and Staphylococcus saprophyticus ATCC 1970 were determined after the administration of single oral doses of gemifloxacin at 320 mg and trovafloxacin at 200 mg to healthy volunteers. Gemifloxacin presented significantly lower experimental versus mathematically predicted UBTs over 72 h, due to the effect of urine on the susceptibility of the E. coli strain. Experimental UBTs were significantly higher for gemifloxacin than trovafloxacin against both strains over 72 h.