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Seventy-two Enterococcus faecium isolates of different origins highly resistant to nourseothricin and streptomycin were studied. Sequencing of a genomic fragment from two isolates identified a gene cluster, aadE-sat4-aphA-3, which has been isolated recently in staphylococci and Campylobacter coli. Patterns of digested PCR products of aadE-sat4-aphA-3 were identical for all isolates.

antimicrobial agents and chemotherapy

Aminoglycoside-Streptothricin Resistance Gene Cluster <i>aadE–sat4–aphA-3</i> Disseminated among Multiresistant Isolates of <i>Enterococcus faecium</i>

Aminoglycoside-Streptothricin Resistance Gene Cluster aadE–sat4–aphA-3 Disseminated among Multiresistant Isolates of Enterococcus faecium