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GAR-936, a new glycylcycline, had lower MICs (&lt; or =0.016 to 0.125 microg/ml) for 201 penicillin- and tetracycline-susceptible and -resistant pneumococcal strains than tetracycline (&lt; or = 0.06 to 128 microg/ml), minocycline (&lt; or =0.06 to 16.0 microg/ml), or doxycycline (&lt; or =0.06 to 32.0 microg/ml). GAR-936 was also bactericidal against 11 of 12 strains tested at the MIC after 24 h, with significant kill rates at earlier time points.

antimicrobial agents and chemotherapy

Antipneumococcal Activities of GAR-936 (a New Glycylcycline) Compared to Those of Nine Other Agents against Penicillin-Susceptible and -Resistant Pneumococci