Open AccessSelf-Inhibitory Peptides Targeting the Neisseria gonorrhoeae MtrCDE Efflux Pump Increase Antibiotic Susceptibility
Author(s) -
Benjamin Evert,
Valentin A Slesarenko,
Jilsy M. J. Punnasseril,
Taha Taha,
Jian Zhan,
Yaoqi Zhou,
Evgeny A. Semchenko,
Kate L. Seib
Publication year - 2022
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.01542-21
Subject(s) - neisseria gonorrhoeae , antibiotics , azithromycin , microbiology and biotechnology , ciprofloxacin , ceftriaxone , efflux , antibiotic resistance , biology , minimum inhibitory concentration , erythromycin , genetics
Neisseria gonorrhoeae is an increasing public health threat due to its rapidly rising incidence and antibiotic resistance. There are an estimated 106 million cases per year worldwide, there is no vaccine available to prevent infection, andN. gonorrhoeae strains that are resistant to all antibiotics routinely used to treat the infection have emerged.