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Upregulated expression of efflux pumps,lpxC target mutations, LpxC protein overexpression, and mutations infabG were previously shown to mediate single-step resistance to the LpxC inhibitor CHIR-090 inP. aeruginosa . Single-step selection experiments using three recently described LpxC inhibitors (compounds 2, 3, and 4) and mutant characterization showed that these mechanisms affect susceptibility to additional novel LpxC inhibitors.

antimicrobial agents and chemotherapy

Mutations Reducing <i>In Vitro</i> Susceptibility to Novel LpxC Inhibitors in <i>Pseudomonas aeruginosa</i> and Interplay of Efflux and Nonefflux Mechanisms

Mutations Reducing In Vitro Susceptibility to Novel LpxC Inhibitors in Pseudomonas aeruginosa and Interplay of Efflux and Nonefflux Mechanisms