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Anthracene-polyamine conjugates inhibit thein vitro proliferation of the intraerythrocytic human malaria parasitePlasmodium falciparum , with 50% inhibitory concentrations (IC50 s) in the nM to μM range. The compounds are taken up into the intraerythrocytic parasite, where they arrest the parasite cell cycle. Both the anthracene and polyamine components of the conjugates play a role in their antiplasmodial effect.

Anthracene-Polyamine Conjugates Inhibit In Vitro Proliferation of Intraerythrocytic Plasmodium falciparum Parasites