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Next-generation sequencing of 6mcr-1 -harboringEscherichia coli andKlebsiella pneumoniae isolates collected from a tertiary care hospital in China revealed significant sequence variations in the regions flanking themcr-1 gene. While sequence variations significantly affected the expression and promoter activity ofmcr-1 , themcr-1 gene expression levels did not correlate with thein vitro colistin resistance levels, which warrants further in-depth investigations.

antimicrobial agents and chemotherapy

Promoter Variation and Gene Expression of <i>mcr-1</i> -Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital

Promoter Variation and Gene Expression of mcr-1 -Harboring Plasmids in Clinical Isolates of Escherichia coli and Klebsiella pneumoniae from a Chinese Hospital