Open AccessAn affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models
Author(s) -
Bert Schepens,
Loes van Schie,
Wim Nerinckx,
Kenny Roose,
Wander Van Breedam,
Daria Fijałkowska,
Simon Devos,
Wannes Weyts,
Sieglinde De,
Sandrine Vanmarcke,
Chiara Lonigro,
Hannah Eeckhaut,
Dries Van Herpe,
Jimmy Borloo,
Ana Oliveira,
João Paulo Portela Catani,
Sarah Creytens,
Dorien De Vlieger,
Gitte Michielsen,
Jackeline Cecilia Zavala Marchan,
George D. Moschonas,
Iebe Rossey,
Koen Sedeyn,
Annelies Van Hecke,
Xin Zhang,
Lana Langendries,
Sofie Jacobs,
Sebastiaan ter Horst,
Laura Seldeslachts,
Laurens Liesenborghs,
Robbert Boudewijns,
Hendrik Jan Thibaut,
Kai Dallmeier,
Greetje Vande Velde,
Birgit Weynand,
Julius Beer,
Daniel Schnepf,
Annette Ohnemus,
Isabel Remory,
Caroline S. Foo,
Rana Abdelnabi,
Piet Maes,
Suzanne Kaptein,
Joana RochaPereira,
Dirk Jochmans,
Leen Delang,
Frank Peelman,
Peter Staeheli,
Martin Schwemmle,
Nick Devoogdt,
Dominique Tersago,
Massimiliano Germani,
James T. Heads,
Alistair J. Henry,
Andrew G. Popplewell,
M N Ellis,
Kevin Brady,
Alison Turner,
Bruno Dombrecht,
Catelijne Stortelers,
Johan Neyts,
Nico Callewaert,
Xavier Saelens
Publication year - 2021
Publication title -
science translational medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.819
H-Index - 216
eISSN - 1946-6242
pISSN - 1946-6234
DOI - 10.1126/scitranslmed.abi7826
Subject(s) - antibody , virology , chinese hamster ovary cell , neutralizing antibody , epitope , biology , coronavirus , peptide library , vero cell , covid-19 , virus , immunology , receptor , medicine , peptide sequence , gene , infectious disease (medical specialty) , disease , biochemistry , pathology
A heavy chain–only antibody drug with broad SARS coronavirus neutralizing activity protects mice and hamsters.