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Metastatic bone disease of the spine was evaluated in 20 consecutive patients at the time of the first metastasis of breast cancer. All patients presented other bone and visceral metastatic lesions and/or positive bone marrow biopsy. The serum CEA and CA 15-3 levels were always increased. The spine of patients was examined by anterior-posterior and lateral plain X-Ray films of the spine, bone scintigraphy after intravenous injection of Tc-99 m labeled methyldiphosphonate (Tc 90 m MDP) and MR using T1 spin echo sequence in the sagittal plane. The sensitivity of the three methods to detect bone vertebrae metastases was evaluated. The metastatic involvement of vertebral bodies was detected more often by MR than conventional radiography or bone scintigraphy. Early imminent impingement of the spinal cord can be observed, before neurologic symptoms.

Financial Transaction Tax: Determination of Economic Impact Under DSGE Model