Open AccessEvidence of the involvement of K + channels and PPAR γ receptors in the antidepressant‐like activity of diphenyl diselenide in mice
Author(s) -
Wilhelm Ethel A.,
Jesse Cristiano R.,
Bortolatto Cristiani F.,
Barbosa Nilda B.V.,
Nogueira Cristina W.
Publication year - 2010
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.2010.01132.x
Subject(s) - diphenyl diselenide , diselenide , antidepressant , receptor , pharmacology , chemistry , medicine , neuroscience , psychology , biochemistry , hippocampus , selenium , organic chemistry
Abstract Objectives This study investigated the involvement of different types of K + channels and PPAR γ receptors in the antidepressant‐like effect of diphenyl diselenide in mice. Methods Mice were pretreated with subeffective doses of K + channel inhibitors (tetraethylammonium, glibenclamide, charybdotoxin and apamin), openers (cromakalim, minoxidil), GW 9662 (a PPAR γ antagonist) or vehicle. Thirty minutes later the mice received diphenyl diselenide in either an effective or a subeffective dose, 30 min before a tail‐suspension test. Key findings Pre‐treatment with tetraethylammonium, charybdotoxin or apamin combined with a subeffective dose of diphenyl diselenide was effective in decreasing the immobility time in the mouse tail‐suspension test. The reduction in the immobility time elicited by an effective dose of diphenyl diselenide in this test was prevented by the pretreatment of mice with minoxidil and GW 9662. Conclusions Diphenyl diselenide elicited an antidepressant‐like effect and this action was mediated, at least in part, by modulation of K + channels and PPAR γ receptors.