Open AccessCharacterization of the Influence of some Cyclodextrins on the Stratum Corneum from the Hairless Mouse
Author(s) -
BENTLEY M. VITÓRIA L. B.,
VIANNA RENATA F.,
WILSON SUSAN,
COLLETT JOHN H.
Publication year - 1997
Publication title -
journal of pharmacy and pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.745
H-Index - 118
eISSN - 2042-7158
pISSN - 0022-3573
DOI - 10.1111/j.2042-7158.1997.tb06813.x
Subject(s) - stratum corneum , hairless , corneocyte , differential scanning calorimetry , chemistry , fourier transform infrared spectroscopy , permeation , chromatography , biophysics , biochemistry , chemical engineering , biology , medicine , pathology , physics , membrane , engineering , thermodynamics
Abstract Differential scanning calorimetry (DSC), Fourier‐transform infrared (FTIR) spectroscopy and transmission electron microscopy (TEM) have been used to determine the influence of β‐cyclodextrin (β‐CyD), hydroxypropyl‐β‐CyD (HP‐β‐CyD) and γ‐CyD on the structural properties of the stratum corneum from the hairless mouse. Some modest changes in the stratum corneum lipid transition temperature were induced by HP‐β‐CyD and blue shifts were observed in the FTIR spectra of the C–H asymmetric and symmetric stretching of the lipids from the stratum corneum. Results from TEM studies indicated that HP‐β‐CyD caused removal and possible disorganization of the lipid matrix that envelopes the corneocytes of the stratum corneum, whereas no effect was seen after treatment of the samples with β‐CyD and γ‐CyD. These results suggest that HP‐β‐CyD can increase the permeability of the stratum corneum possibly as a result of extraction of lipids, and might thus enhance drug permeation through the skin.