Open AccessThe Serratia ‐type hemolysin of Chromobacterium violaceum
Author(s) -
Brumbach Kevin C.,
Eason Bryan D.,
Anderson Lamont K.
Publication year - 2007
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.2006.00566.x
Subject(s) - chromobacterium violaceum , operon , quorum sensing , virulence , microbiology and biotechnology , serratia , biology , hemolysin , gene , genetics , biofilm , prodigiosin , bacteria , serratia marcescens , pseudomonas , escherichia coli
Chromobacterium violaceum is a Gram‐negative opportunistic human pathogen and an inhabitant of tropical soils and waterways. Although known primarily for the synthesis of the pigment violacein, and more recently as a reporter strain for quorum sensing, clinical reports of chromobacteriosis comprise the largest block of published literature on this organism. Genome sequencing has revealed many potential virulence factors in this microorganism, and this paper establishes the presence in C. violaceum of a Serratia type‐hemolysin (ChlA) and transporter (ChlB). We also show that the hemolysin operon includes a third gene ( chlC ) that is predicted to encode a phosphorylation domain similar to the receiver domain of response regulators in bacterial signal transduction systems.