Open AccessImmunization with killed Escherichia coli increases resistance of lipopolysaccharide‐hyporesponsive C3H/HeJ mice to experimental urinary tract infection
Author(s) -
James Rourke F.,
Cabrera Edelberto J.
Publication year - 1988
Publication title -
fems microbiology letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.899
H-Index - 151
eISSN - 1574-6968
pISSN - 0378-1097
DOI - 10.1111/j.1574-6968.1988.tb02962.x
Subject(s) - escherichia coli , urinary system , regimen , microbiology and biotechnology , immunization , lipopolysaccharide , strain (injury) , immunology , medicine , biology , immune system , biochemistry , gene
Abstract C3H/HeJ mice are highly susceptible to experimental ascending urinary tract infection. After a 4‐week intraperitoneal immunization regimen with killed Escherichia coli , these mice became more resistant to urinary tract infection. The level of resistance induced by this regimen in this strain was similar to that of the normally more resistant C3HeB/FeJ strain of mouse and was evident from 3 to 14 days after transurethral challenge with E. coli . Increased resistance also developed after a 2‐ or 3‐week immunization regimen, but this resistance was not apparent until 14 days after challenge.