Open AccessRole of CD86 (B7–2) in triggering of antigen‐specific IgE antibody response by lipopolysaccharide
Author(s) -
Jiang G.Z,
Kato Y,
Sugiyama T,
Koide N,
Chakravortty D,
Kawai M,
Fukada M,
Yoshida T,
Yokochi T
Publication year - 1998
Publication title -
fems immunology & medical microbiology
Language(s) - English
Resource type - Journals
eISSN - 1574-695X
pISSN - 0928-8244
DOI - 10.1111/j.1574-695x.1998.tb01178.x
Subject(s) - lipopolysaccharide , cd86 , antigen , biology , antibody , ascaris , immunoglobulin e , immunology , microbiology and biotechnology , immune system , t cell , helminths
Abstract The role of CD86 in triggering of ascaris extract‐specific IgE antibody response by lipopolysaccharide was studied. The simultaneous administration of anti‐CD86 antibody with ascaris extract and lipopolysaccharide prevented the production of IgE antibody response to ascaris extract. CD86 + cells were detected in peritoneal cavities and spleens of mice injected intraperitoneally with lipopolysaccharide. CD86 + cells appeared in peritoneal cavities and spleens eight hours after lipopolysaccharide injection, and they were detectable for a week. CD86 + cells in peritoneal cavities and spleens were mainly surface Ig‐positive B‐cells and some Ig‐negative cells. It was suggested that lipopolysaccharide induced the expression of CD86 mainly on B‐cells, and that CD86 + cells induced by lipopolysaccharide injection might play an important role as antigen‐presenting cells on triggering of ascaris extract‐specific IgE antibody response by lipopolysaccharide.