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We propose a method for human embryo grading with its images. This grading has been achieved by positive-negative classification (i.e., live birth or non-live birth). However, negative (non-live birth) labels collected in clinical practice are unreliable because the visual features of negative images are equal to those of positive (live birth) images if these non-live birth embryos have chromosome abnormalities. For alleviating an adverse effect of these unreliable labels, our method employs Positive-Unlabeled (PU) learning so that live birth and non-live birth are labeled as positive and unlabeled, respectively, where unlabeled samples contain both positive and negative samples. In our method, this PU learning on a deep CNN is improved by a learning-to-rank scheme. While the original learning-to-rank scheme is designed for positive-negative learning, it is extended to PU learning. Furthermore, overfitting in this PU learning is alleviated by regularization with mutual information. Experimental results with 643 time-lapse image sequences demonstrate the effectiveness of our framework in terms of the recognition accuracy and the interpretability. In quantitative comparison, the full version of our proposed method outperforms positive-negative classification in recall and F-measure by a wide margin (0.22 vs. 0.69 in recall and 0.27 vs. 0.42 in F-measure). In qualitative evaluation, visual attentions estimated by our method are interpretable in comparison with morphological assessments in clinical practice.

Embryo Grading With Unreliable Labels Due to Chromosome Abnormalities by Regularized PU Learning With Ranking