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Changes in skin appearance are among the most recognizable symptoms of a number of medical conditions. The interpretation of such changes, however, may be inadvertently biased by normal physiological processes affecting skin optical properties. In this paper, we assess the impact of one of the most common of these processes, tanning, on variations in skin chromatic attributes elicited by two ubiquitous and serious medical conditions, anemia and hyperbilirubinemia. We employ a first-principles investigation approach centered on the use of predictive computer simulations of light and skin interactions, and on well-established colorimetry methods. In our in silico experiments, we considered skin chromatic attributes resulting from distinct anemia severity levels and hyperbilirubinemia tox-icity stages. Our findings highlight qualitative and quantitative aspects that need to be considered in the visual screening and monitoring of these conditions, notably when they occur with the concomitant presence of tanning-induced changes in the cutaneous tissues&#x0027; melanin pigmentation and thickness.

In Silico Assessment of Tanning Masking Effects on Skin Chromatic Attributes Elicited by Anemia and Hyperbilirubinemia