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The title chalcone derivative, C 19 H 20 O 5 , adopts a trans configuration with respect to the olefinic C=C double bond. The 2-hy-droxy-4-methyl-phenyl ring is coplanar with the attached enone bridge [torsion angle = -179.96 (14)°], where this plane is nearly perpendicular to the 2,4,6-tri-meth-oxy-phenyl ring [dihedral angle = 75.81 (8)°]. In the crystal, mol-ecules are linked into chains propagating along [010] by an O-H⋯O hydrogen bond. These chains are further connected into centrosymmetric dimer chains via weak C-H⋯O inter-actions. The conformations of related chalcone derivatives are surveyed and all of these structures adopt a skeleton with two almost orthogonal aromatic rings.

Crystal structure of (E)-3-(2-hydroxy-4-methylphenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-one