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1Department of Applied Biological Chemistry, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan. 2Division of Applied Life Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Naka-ku, Sakai 559-8531, Japan. 3Division of Applied Life Sciences, Kyoto University, Kitashirakawa-Oiwakecho, Sakyoku, Kyoto 606-8502, Japan. 4Faculty of Bioenvironmental Science, Kyoto Gakuen University, Sogabe-cho, Kameoka 6218555, Japan. E-mail:ahmqin@mail.ecc.u-tokyo.ac.jp

Structure change for substrate recognition in conjugated polyketone reductase