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The discovery of new 5-HT1A receptor ligands with high affinity and selectivity is an area of research in medicinal chemistry. Structural investigations of them are very important for the designing of new, effective and safe drugs. Long chain arylpiperazines with an amide or imide moiety represent one of the most important classes of the 5-HT1A receptor ligands. They are regarded as potential drugs in the therapy of anxiety, depression, memory dysfunction and learning. The most frequently investigated member of them is buspirone. As a part of our work on the development of novel piperazine derivatives with central nervous system activity, new analoques of buspirone have been obtained and their crystal and molecular structures have been determined by X-ray structure analysis.

Structural characterization of new potential 5-HT1Areceptor ligands

Structural characterization of new potential 5-HT_1Areceptor ligands