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Dissipative Particle Dynamics (DPD) is becoming a popular particle basedmethod to study flow through microchannels due to the ease with which thepresence of biological cells or DNA chains can be modeled. Many Lab-On-Chip(LOC) devices require the ability to manipulate the transport of cells or DNAchains in the fluid flow. Microchannel surfaces coated with combinations ofhydrophilic and hydrophobic materials have been found useful for this purpose.In this work, we have numerically studied the hydrodynamics of a steadynonuniform developing flow between two infinite parallel plates withhydrophilic and hydrophobic surfaces using DPD for the first time. Thehydrophobic and hydrophilic surfaces were modeled using partial-slip andno-slip boundary conditions respectively in the simulations. We also propose anew method to model the inflow and outflow boundaries for the DPD simulations.The simulation results of the developing flow match analytical solutions fromcontinuum theory for no-slip and partial-slip surfaces to good accord.  The entrance region constitutes a considerable fraction of the channel lengthin miniaturized devices. Thus it is desirable for the length of the developingregion to be short as most microfluidic devices such as cell or DNA separatorsand mixers are designed for the developed flow field. We studied the effect ofa hydrophilic strip near the inlet of a microchannel on the effectivedeveloping length. We find that the presence of the hydrophobic stripsignificantly reduces the developing length.

Hydrodynamics of the Developing Region in Hydrophobic Microchannels: A Dissipative Particle Dynamics Study