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In carbon-therapy, the interaction of the incoming beam with human tissuesmay lead to the production of a large amount of nuclear fragments and secondarylight particles. An accurate estimation of the biological dose deposited intothe tumor and the surrounding healthy tissues thus requires sophisticatedsimulation tools based on nuclear reaction models. The validity of such modelsrequires intensive comparisons with as many sets of experimental data aspossible. Up to now, a rather limited set of double di erential carbonfragmentation cross sections have been measured in the energy range used inhadrontherapy (up to 400 MeV/A). However, new data have been recently obtainedat intermediate energy (95 MeV/A). The aim of this work is to compare thereaction models embedded in the GEANT4 Monte Carlo toolkit with these new data.The strengths and weaknesses of each tested model, i.e.G4BinaryLightIonReaction, G4QMDReaction and INCL++, coupled to two di fferentde-excitation models, i.e. the generalized evaporation model and the Fermibreak-up are discussed.

Benchmarking GEANT4 nuclear models for hadron therapy with 95 MeV/nucleon carbon ions