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In fission yeast, the DNA damage sensor kinases Tel1 ATM  and Rad3 ATR  exist at telomeres and are required for telomere maintenance, but the biological role they play at telomeres is not known. Here we show that the telomere protein Ccq1 is phosphorylated at Thr 93 (threonine residue at amino acid 93) by Tel1 ATM  and Rad3 ATR  both in vitro and in vivo. A  ccq1  mutant in which alanine was substituted for Thr 93 failed to recruit telomerase to telomeres and showed gradual shortening of telomeres. These results indicate that the direct phosphorylation of Ccq1 Thr 93 by Tel1 and Rad3 is involved in the recruitment of telomerase to elongate telomeres.

Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast

Tel1^ATM and Rad3^ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast