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Cell cycle exit is required for terminal differentiation of many cell types. The retinoblastoma protein  Rb  has been implicated both in cell cycle exit and differentiation in several tissues. Rb  is negatively regulated by cyclin-dependent kinases ( Cdk s). The main effectors that down-regulate  Cdk activity to activate  Rb  are not known in the lens or other tissues. In this study, using multiple mutant mice, we show that the Cdk  inhibitors  p27 KIP1   and p57 KIP2   function redundantly to control cell cycle exit and differentiation of lens fiber cells and placental trophoblasts. These studies demonstrate that  p27 KIP1  and  p57 KIP2   are critical terminal effectors of signal transduction pathways that control cell differentiation.

Cooperation between the Cdk inhibitors p27KIP1 and p57KIP2 in the control of tissue growth and development

Cooperation between the Cdk inhibitors p27^KIP1 and p57^KIP2 in the control of tissue growth and development