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The Spatial Convolution Model (SCM) analyzes allostery based on the spatialevolution of the docking protein elastic media, whereby convolution of themedia in response to wave propagation is solved as a function of Z fluctuationsand backbone vibration modes. We show that although the elastic media is acomplex three-dimensional structure allostery behaves as if it occurs along astretched oscillating string, where inhomogeneities along the string effectlocal entropies responsible for ligand binding and transduction of allostericwaves. To identify inhomogeneities along the string, we ignored local densityand tension changes during wave propagation and resolved helix wave andphysical properties by applying molecular string and beam bending theories.Importantly, we show that allostery occurs at three major scales and thatpropagation of standing waves create a rolling entropy which drives entropytransfers between fields. Conversion of resonance energy to quantum harmonicoscillators allowed us to consider effects of damping and interactions with thesurrounding media as well as to model effects of residue interaction strengthon entropy transfer.

A Comprehensive Analysis of Allostery in 14-3-3 $\zeta$ Docking Proteins using the Spatial Convolution Model (SCM)