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3T3-L1        .   (MRE) ${\alpha}$ -amylase ${\alpha}$ -glucosidase, pancreatic lipase       $7.86{\pm}0.36$ , $0.12{\pm}0.03$ , $7.93{\pm}0.11mg/mL$  $IC_{50}$      .  3T3-L1    MRE       .       adipogenesis  lipogenesis     ,          FAS ACC   adipogenesis lipogenesis    $PPAR{\gamma}$  $C/EBP{\alpha}$ , SREBP-1c    . qRT-PCR  ,   anti-adipogenesis       .                .          . 【Anti-obese effects of mulberry (Morus alba L.) root bark was investigated in vitro by measuring its inhibitory effect against 3T3-L1 preadipocyte differentiation and digestive enzymes such as ${\alpha}$ -amylase, ${\alpha}$ -glucosidase and pancreatic lipase. Ethanol extract of mulberry root bark (MRE) showed the potent inhibitory activities on ${\alpha}$ -amylase, ${\alpha}$ -glucosidase and pancreatic lipase with $IC_{50}$ values of $7.86{\pm}0.36$ , $0.12{\pm}0.03$ and $7.93{\pm}0.11mg/mL$ , respectively. Furthermore, MRE significantly suppressed cellular lipid accumulation in 3T3-L1 cells in a dose-dependent manner. To elucidate the mechanism of MRE, we performed qRT-PCR and Western blotting for the expression of genes related with adipogenesis and lipogenesis. Treatment of MRE markedly suppressed the protein expression of $PPAR{\gamma}$ , $C/EBP{\alpha}$ and SREBP-1c, as well as FAS and ACC, which are the key transcription factors and metabolic enzymes in adipogenesis and lipogenesis. In addition, qRT-PCR analysis indicated that the anti-adipogenesis effect of MRE might be due to its inhibition at transcription levels. These results demonstrate that MRE can effectively suppress adipocyte differentiation and inhibit key enzymes related to obesity. Our findings suggest that mulberry root bark may have a potential benefit in preventing obesity.】

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